Palacio de Monroy, also known as the 'House of the Two Towers,' is a testament to Plasencia's rich medieval past. Built in the 14th century, it was a significant noble residence, most notably the birthplace of Doña María Rodríguez de Monroy, a formidable figure who led the Salamanca War of the Banderías. The palace's history is intertwined with powerful families like the Monroy and Carvajal, reflecting the political and social dynamics of the era. Its walls have witnessed visits from royalty, including King Ferdinand the Catholic, and esteemed religious figures like Saint Peter of Alcántara, underscoring its historical importance.

The architecture itself tells a story of time and change. The oldest surviving part is a 13th-century tower, bearing the Carvajal coat of arms, a symbol of the family's long-standing presence. The palace's name, 'House of the Two Towers,' refers to a second tower that once stood but was tragically demolished in the 19th century due to damage sustained in the devastating 1755 earthquake. The facade was further altered in the 19th century with a neo-Gothic/Renaissance overlay, featuring large openings and the distinctive original Gothic doorway with high reliefs of two lions. These lions are not merely decorative; they historically symbolized the house's autonomy, signifying that it was subject to no jurisdiction other than its own.

Currently, Palacio de Monroy is privately owned and has faced complexities due to multiple inheritors. Despite these challenges, efforts are underway to consolidate and repurpose the structure, aiming to preserve its historical integrity. While interior access may be restricted due to ongoing restoration, the exterior facade and towers remain a compelling sight, offering a tangible connection to Plasencia's medieval heritage. Visitors can appreciate the blend of architectural styles and imagine the historical events that unfolded within its walls.